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    Marie Curie Initial Training Networks (ITN): “BIOART”
    funded by
    Training network for developing innovative (bio)artificial devices for treatment of kidney  and liver disease

     

    EInHorn
    funded by
    Innovative hollow fibre membranes for next generation wound healing management

     

    NPore
    funded by
    Development, characterisation and validation of nanoparticles for adsorption of hydrophobic uremic toxins in renal failure patients
    BIOART: Training network for developing innovative (bio)artificial devices for treatment of kidney and liver disease

    Projektpartner:

    • University of Twente – MIRA Institute, Faculty of Science and Technology Biomaterials Science and Technology, NL
    • Université Paul Sabatier (UPS), Laboratoire de Génie Chimique (LGC), F
    • Stichting Katholieke Universiteit Nijmegen, Dept. Pharmacology and Toxicology, NL
    • Centre national de la Recherche Scientifique Université Technologique de Compiègne, F
    • Consiglio Nazionale delle Ricerche (CNR) Institute on Membrane Technology – ITM, IT
    • University of Leipzig Biotechnological- Biomedical Center (BBZ), DE
    • Università della Calabria, Department of Chemical Engineering and Materials, IT
    • EXcorLab GmbH, DE
    • GVS S.P.A, IT
    • Bionethos, DE
    • European Membrane House, BE

    Homepage: http://www.bioart-fp7.eu/

    EINHORN: Innovative hollow fibre membranes for next generation wound healing management

    Project partner:

    • Membrana GmbH, Wuppertal
    • StemCellSystems GmbH, Berlin

    Description of the project:

    The joint research project deals with an innovative surgical dressing for the treatment of burns and chronic wounds. The concept is based on a special membrane to be used in the sterile wound cover enabling the continuous supply with essential nutrients for the skin cells. This forms optimal ambient conditions for regenerating cells and improved wound healing, without exhibiting the negative properties of gauze or non-woven pads. Fewer complications are expected in future through accelerated healing and reduced keloid formation resulting in a considerably augmented of quality of life for the patients affected. Both from the medical and the economic point of view the new wound management system should show significant improvements.

    In the project eXcorLab is a sub contractor of Membrana GmbH. The work packages comprise cytotoxicity and pyrogenicity testing of the wound dressing and its influence on wound healing in an in vitro skin model

    Homepage: http://medi-wing.de/foerdermassnahmen/biodisposables/laufende-vorhaben/einhorn/

    NPORE: Development, characterisation and validation of nanoparticles for adsorption of hydrophobic uremic toxins in renal failure patients

    Project partner:

    • University of Hyderabad, Hyderabad, India
    • Charite, University Berlin, Exp. Nephrology and Hypertension, Berlin, Germany
    • Helmholtz Zentrum Geesthacht, Center for Biomaterial Development, Teltow, Germany

    Description of the project:

    Patients with chronic kidney disease (CKD) and also those on dialysis (CKD-5D) show an increased cardiovascular mortality and morbidity due to several risk factors including hyperphosphataemia, diabetes mellitus, hypertension, anaemia, dyslipidemia and uremic retention solutes toxicity. Protein-bound uremic toxins, such as phenylacetic acid, indoxyl sulfate and p-cresylsulfate contribute substantially to the progression of chronic kidney disease and cardiovascular disease (CVD). However, based on their protein-binding these hydrophobic toxins are poorly cleared during conventional hemodialysis or even hemodiafiltration and thus accumulate in CKD-5Dpatients. Therefore, this project aims at the development, characterisation and validation of adsorbant particles for the removal of uremic toxins from plasma of chronic renal failure patients.

    The consortium is composed of four partners covering synthetic, analytical and bio-safety and compatability aspects. HZG will develop new adsorbant particles and will modify already available (patent-protected) materials for the adsorption of uremic toxins. CHA will characterise the particles regarding their chemical and biochemical properties. EXC will use its strong experience in testing of biomaterials for biocompatibility aspects. UNH will test side effects, if any, of the particles on cultured human- blood cells (monocytes) and vascular endothelial and smooth muscle cells.

     

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